BDBM32212 1H-indol-5-ol::cid_16054

SMILES: Oc1ccc2[nH]ccc2c1

InChI Key: InChIKey=LMIQERWZRIFWNZ-UHFFFAOYSA-N

Data: 5 IC50  2 Kd  1 EC50

PDB links: 3 PDB IDs match this monomer. 79 PDB IDs contain this monomer as substructures. 79 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 32212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM32212 (1H-indol-5-ol | cid_16054) Show SMILES Oc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	7.4	23
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay					Assay Description A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2Q23XM6
					More data for this Ligand-Target Pair
large T antigen (Simian virus 40)	BDBM32212 (1H-indol-5-ol | cid_16054) Show SMILES Oc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	8.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Specialized Biocontainment Screening Center Curated by PubChem BioAssay					Assay Description A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag Southern Re...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2M61HQ8
					More data for this Ligand-Target Pair
DNA repair and recombination protein (RadA) (Pyrococcus furiosus)	BDBM32212 (1H-indol-5-ol | cid_16054) Show SMILES Oc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	2.10E+6	n/a	n/a	n/a	n/a	n/a
University of Cambridge					Assay Description The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...				Chembiochem 14: 332-42 (2013) Article DOI: 10.1002/cbic.201200521 BindingDB Entry DOI: 10.7270/Q2QF8RHG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM32212 (1H-indol-5-ol | cid_16054) Show SMILES Oc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Activity at human alpha-7 nACh receptor expressed in Xenopus laevis oocyte assessed as increase in acetylcholine-induced current				J Med Chem 51: 701-12 (2008) Article DOI: 10.1021/jm070256g BindingDB Entry DOI: 10.7270/Q2WS8V3B
					More data for this Ligand-Target Pair
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human))	BDBM32212 (1H-indol-5-ol | cid_16054) Show SMILES Oc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.10E+6	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to RAD51 (unknown origin) by isothermal calorimetry				Bioorg Med Chem Lett 25: 2461-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.089 BindingDB Entry DOI: 10.7270/Q2SF2XVC
					More data for this Ligand-Target Pair
Tyrosinase (Mus musculus (Mouse))	BDBM32212 (1H-indol-5-ol | cid_16054) Show SMILES Oc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Advanced Industrial Science and Technology Curated by ChEMBL					Assay Description Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation				Bioorg Med Chem Lett 19: 4178-82 (2009) Article DOI: 10.1016/j.bmcl.2009.05.115 BindingDB Entry DOI: 10.7270/Q2BR8S70
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (Human))	BDBM32212 (1H-indol-5-ol | cid_16054) Show SMILES Oc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
deCODE biostructures, Inc. Curated by ChEMBL					Assay Description Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...				J Med Chem 52: 4694-715 (2009) Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N
					More data for this Ligand-Target Pair				3D Structure (crystal)
Leukotriene A4 hydrolase (Homo sapiens (Human))	BDBM32212 (1H-indol-5-ol | cid_16054) Show SMILES Oc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
deCODE biostructures, Inc. Curated by ChEMBL					Assay Description Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE				J Med Chem 52: 4694-715 (2009) Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N
					More data for this Ligand-Target Pair				3D Structure (crystal)