BDBM322539 5-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)chroman-6-yl]oxy-3,4-dihydro-1H-1,8-naphthyridin-2-one::US10183939, Example 17

SMILES: O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(no3)-c3ccccc3)ccnc2N1

InChI Key: InChIKey=HDFZZHXQYZSHRT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322539   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-RAF (Y340D Y341D) (Homo sapiens (Human))	BDBM322539 (5-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)chroman-6-yl]o...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(no3)-c3ccccc3)ccnc2N1 Show InChI InChI=1S/C25H20N4O4/c30-22-9-7-19-21(10-11-26-24(19)27-22)32-18-6-8-20-16(13-18)12-17(14-31-20)25-28-23(29-33-25)15-4-2-1-3-5-15/h1-6,8,10-11,13,17H,7,9,12,14H2,(H,26,27,30)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
B-Raf (V600E) (Homo sapiens (Human))	BDBM322539 (5-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)chroman-6-yl]o...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(no3)-c3ccccc3)ccnc2N1 Show InChI InChI=1S/C25H20N4O4/c30-22-9-7-19-21(10-11-26-24(19)27-22)32-18-6-8-20-16(13-18)12-17(14-31-20)25-28-23(29-33-25)15-4-2-1-3-5-15/h1-6,8,10-11,13,17H,7,9,12,14H2,(H,26,27,30)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent					Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...				US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair