BDBM323819 US10189809, Compound I-71
SMILES: COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2ccsc2)n(Cc2ccccc2F)n1
InChI Key: InChIKey=YOTRPEOZXVUAPN-UHFFFAOYSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM323819 (US10189809, Compound I-71) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a |
Ironwood Pharmaceuticals, Inc. US Patent | Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds.... | US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6 | |||||||||||
More data for this Ligand-Target Pair |