BDBM32422 Benzo[c][2,7]naphthyridine, 9

SMILES: COCCOc1cc2ncc3c(N)nc(cc3c2cc1OC)-n1ccnc1

InChI Key: InChIKey=QSSGYSRUMIOURP-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 32422   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) (Homo sapiens (Human))	BDBM32422 (Benzo[c][2,7]naphthyridine, 9) Show SMILES COCCOc1cc2ncc3c(N)nc(cc3c2cc1OC)-n1ccnc1 Show InChI InChI=1S/C19H19N5O3/c1-25-5-6-27-17-9-15-13(7-16(17)26-2)12-8-18(24-4-3-21-11-24)23-19(20)14(12)10-22-15/h3-4,7-11H,5-6H2,1-2H3,(H2,20,23)	PDB MMDB B.MOAD GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	7.4	23
Wyeth Research					Assay Description A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...				Bioorg Med Chem Lett 19: 5225-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.007 BindingDB Entry DOI: 10.7270/Q2XK8CXJ
					More data for this Ligand-Target Pair				3D Structure (crystal)