BDBM325529 2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-6-yl)-1H-pyrazol-1-yl)propan-1-ol::US10189845, Example 191::US10730880, Example 191

SMILES: CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1

InChI Key: InChIKey=QVZXJVILZBKCPS-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 325529   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM325529 (2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1 Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020)
					More data for this Ligand-Target Pair