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SMILES: Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1

InChI Key: InChIKey=BHSHOGSANFAXLR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332053   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM332053
PNG
(US10189854, Compound 1 | [1-[5-(2-Fluorophenyl)-py...)
Show SMILES Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H23FN4O2/c26-21-4-2-1-3-19(21)18-14-27-24(28-15-18)30-16-25(7-8-25)20-6-5-17(13-22(20)30)23(31)29-9-11-32-12-10-29/h1-6,13-15H,7-12,16H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...

US Patent US10189854 (2019)


BindingDB Entry DOI: 10.7270/Q2N87CW4
More data for this
Ligand-Target Pair