BDBM332584 5-chloroindol-2-yl 7-{[4-(trifluoromethyl)phenyl]carbonyl}-2,7-diazaspiro[3.5]non-2-yl ketone::US10196369, Compound C39

SMILES: FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1

InChI Key: InChIKey=JMEZAOUBYWPEGD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332584   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G-protein coupled receptor 183 (Homo sapiens (Human))	BDBM332584 (5-chloroindol-2-yl 7-{[4-(trifluoromethyl)phenyl]c...) Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1 Show InChI InChI=1S/C24H21ClF3N3O2/c25-18-5-6-19-16(11-18)12-20(29-19)22(33)31-13-23(14-31)7-9-30(10-8-23)21(32)15-1-3-17(4-2-15)24(26,27)28/h1-6,11-12,29H,7-10,13-14H2	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...				US Patent US10196369 (2019) BindingDB Entry DOI: 10.7270/Q2BR8V88
					More data for this Ligand-Target Pair