BDBM333382 3-[(1R)-1-{[3-(1- Benzofuran-2- yl)imidazo[1,2-b]pyridazin- 6-yl]oxy}-2- (methylamino)ethyl]phenol::US9730929, Example 3

SMILES: CN(C[C@H](O)c1cccc(O)c1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=LGMQDWYYUWDACG-IBGZPJMESA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333382   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM333382 (3-[(1R)-1-{[3-(1- Benzofuran-2- yl)imidazo[1,2-b]p...) Show SMILES CN(C[C@H](O)c1cccc(O)c1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r| Show InChI InChI=1S/C23H20N4O3/c1-26(14-19(29)15-6-4-7-17(28)11-15)23-10-9-22-24-13-18(27(22)25-23)21-12-16-5-2-3-8-20(16)30-21/h2-13,19,28-29H,14H2,1H3/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US9730929 (2017) BindingDB Entry DOI: 10.7270/Q28S4S1H
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