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BDBM336372 US9744172, Compound UNC983A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC

InChI Key: InChIKey=VTMQYPWKWYVLIV-WEBLMRDCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336372   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM336372
PNG
(US9744172, Compound UNC983A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC |r,wD:15.15,(-7.34,-3.23,;-6.01,-2.46,;-4.67,-3.23,;-3.34,-2.46,;-2,-3.23,;-.67,-2.46,;-.67,-.92,;.66,-.15,;2,-.92,;3.46,-.44,;4.37,-1.69,;3.46,-2.93,;3.86,-4.42,;5.35,-4.82,;5.75,-6.31,;4.66,-7.4,;5.05,-8.88,;3.17,-7,;2.77,-5.51,;2,-2.46,;.66,-3.23,;3.86,1.05,;5.35,1.45,;5.75,2.93,;4.66,4.02,;3.17,3.62,;2.77,2.14,;5.05,5.51,;6.59,5.51,;3.72,6.28,;5.45,7,;6.94,7.4,;7.34,8.88,)|
Show InChI InChI=1S/C23H32N6O3S/c1-3-5-14-24-23-25-15-20-21(16-6-12-19(13-7-16)33(31,32)26-4-2)28-29(22(20)27-23)17-8-10-18(30)11-9-17/h6-7,12-13,15,17-18,26,30H,3-5,8-11,14H2,1-2H3,(H,24,25,27)/t17?,18-
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US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...

US Patent US9744172 (2017)


BindingDB Entry DOI: 10.7270/Q2PR7Z30
More data for this
Ligand-Target Pair