BindingDB logo
myBDB logout

BDBM336487 US9744172, Compound UNC1315A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCCOC

InChI Key: InChIKey=KUOKZPZHCQUNTR-VBCPURSTSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336487   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM336487
PNG
(US9744172, Compound UNC1315A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCCOC |r,wD:15.15,(-10.57,-7.54,;-9.23,-6.77,;-7.9,-7.54,;-6.57,-6.77,;-5.23,-7.54,;-3.9,-6.77,;-3.9,-5.23,;-2.57,-4.46,;-1.23,-5.23,;.23,-4.76,;1.14,-6,;.23,-7.25,;.63,-8.74,;2.12,-9.14,;2.52,-10.62,;1.43,-11.71,;1.83,-13.2,;-.06,-11.31,;-.46,-9.83,;-1.23,-6.77,;-2.57,-7.54,;.63,-3.27,;2.12,-2.87,;2.52,-1.38,;1.43,-.29,;-.06,-.69,;-.46,-2.18,;1.83,1.19,;.29,1.19,;1.06,2.53,;3.31,1.59,;4.4,.5,;3.71,3.08,;5.2,3.48,;5.6,4.96,;4.51,6.05,;3.02,5.66,;2.62,4.17,;4.91,7.54,;3.82,8.63,;6.4,7.94,;6.8,9.43,;8.28,9.83,;8.68,11.31,;10.17,11.71,;10.57,13.2,)|
Show InChI InChI=1S/C33H43N7O5S/c1-4-5-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(2)25-11-7-24(8-12-25)32(42)34-20-6-21-45-3/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...

US Patent US9744172 (2017)


BindingDB Entry DOI: 10.7270/Q2PR7Z30
More data for this
Ligand-Target Pair