BDBM337073 US9745291, Compound 119::US9765068, Compound 119

SMILES: OC(CNC(=O)COc1cccc2CCNCc12)CN1CCc2ccccc2C1

InChI Key: InChIKey=WXZGKBGEDPBBPB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337073   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM337073 (US9745291, Compound 119 | US9765068, Compound 119) Show SMILES OC(CNC(=O)COc1cccc2CCNCc12)CN1CCc2ccccc2C1 Show InChI InChI=1S/C23H29N3O3/c27-20(15-26-11-9-17-4-1-2-5-19(17)14-26)12-25-23(28)16-29-22-7-3-6-18-8-10-24-13-21(18)22/h1-7,20,24,27H,8-16H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...				US Patent US9765068 (2017) BindingDB Entry DOI: 10.7270/Q2959KN3
					More data for this Ligand-Target Pair
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM337073 (US9745291, Compound 119 | US9765068, Compound 119) Show SMILES OC(CNC(=O)COc1cccc2CCNCc12)CN1CCc2ccccc2C1 Show InChI InChI=1S/C23H29N3O3/c27-20(15-26-11-9-17-4-1-2-5-19(17)14-26)12-25-23(28)16-29-22-7-3-6-18-8-10-24-13-21(18)22/h1-7,20,24,27H,8-16H2,(H,25,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9745291 (2017) BindingDB Entry DOI: 10.7270/Q2J1058K
					More data for this Ligand-Target Pair