BDBM340314 (Scheme A): Preparation of 2,2-difluoroethyl (3S)-3-{[2′-amino-5-fluoro-2-(morpholin-4-yl)-4,5′-bipyrimidin-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate::US9758538, Example 2
SMILES: Nc1ncc(cn1)-c1nc(nc(N[C@@]2(CO)CCN(C2)C(=O)OCC(F)F)c1F)N1CCOCC1
InChI Key: InChIKey=RTOREZYNLPQUKM-FQEVSTJZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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PI3-kinase class I (Homo sapiens (Human)) | BDBM340314 ((Scheme A): Preparation of 2,2-difluoroethyl (3S)-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | US Patent | <0.0180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER INC. US Patent | Assay Description The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85... | US Patent US9758538 (2017) BindingDB Entry DOI: 10.7270/Q27D2X70 | |||||||||||
More data for this Ligand-Target Pair |