Found 8 hits for monomerid = 346189 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM346189
(WO2007/084786, Compound 343)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCOC(C2)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C23H24F3N7O2/c24-23(25,26)20-16(13-28-21(27)31-20)17-12-19(30-22(29-17)32-6-9-34-10-7-32)33-8-11-35-18(14-33)15-4-2-1-3-5-15/h1-5,12-13,18H,6-11,14H2,(H2,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM346189
(WO2007/084786, Compound 343)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCOC(C2)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C23H24F3N7O2/c24-23(25,26)20-16(13-28-21(27)31-20)17-12-19(30-22(29-17)32-6-9-34-10-7-32)33-8-11-35-18(14-33)15-4-2-1-3-5-15/h1-5,12-13,18H,6-11,14H2,(H2,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM346189
(WO2007/084786, Compound 343)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCOC(C2)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C23H24F3N7O2/c24-23(25,26)20-16(13-28-21(27)31-20)17-12-19(30-22(29-17)32-6-9-34-10-7-32)33-8-11-35-18(14-33)15-4-2-1-3-5-15/h1-5,12-13,18H,6-11,14H2,(H2,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Mus musculus (Mouse)) | BDBM346189
(WO2007/084786, Compound 343)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCOC(C2)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C23H24F3N7O2/c24-23(25,26)20-16(13-28-21(27)31-20)17-12-19(30-22(29-17)32-6-9-34-10-7-32)33-8-11-35-18(14-33)15-4-2-1-3-5-15/h1-5,12-13,18H,6-11,14H2,(H2,27,28,31) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM346189
(WO2007/084786, Compound 343)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCOC(C2)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C23H24F3N7O2/c24-23(25,26)20-16(13-28-21(27)31-20)17-12-19(30-22(29-17)32-6-9-34-10-7-32)33-8-11-35-18(14-33)15-4-2-1-3-5-15/h1-5,12-13,18H,6-11,14H2,(H2,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Rattus norvegicus (Rat)) | BDBM346189
(WO2007/084786, Compound 343)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCOC(C2)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C23H24F3N7O2/c24-23(25,26)20-16(13-28-21(27)31-20)17-12-19(30-22(29-17)32-6-9-34-10-7-32)33-8-11-35-18(14-33)15-4-2-1-3-5-15/h1-5,12-13,18H,6-11,14H2,(H2,27,28,31) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Rattus norvegicus (Rat)) | BDBM346189
(WO2007/084786, Compound 343)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCOC(C2)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C23H24F3N7O2/c24-23(25,26)20-16(13-28-21(27)31-20)17-12-19(30-22(29-17)32-6-9-34-10-7-32)33-8-11-35-18(14-33)15-4-2-1-3-5-15/h1-5,12-13,18H,6-11,14H2,(H2,27,28,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM346189
(WO2007/084786, Compound 343)Show SMILES Nc1ncc(-c2cc(nc(n2)N2CCOCC2)N2CCOC(C2)c2ccccc2)c(n1)C(F)(F)F Show InChI InChI=1S/C23H24F3N7O2/c24-23(25,26)20-16(13-28-21(27)31-20)17-12-19(30-22(29-17)32-6-9-34-10-7-32)33-8-11-35-18(14-33)15-4-2-1-3-5-15/h1-5,12-13,18H,6-11,14H2,(H2,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |