BDBM347317 2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(4-(3-hydroxy-2,2-dimethylpropyl)-3-(trifluoromethyl)phenyl)acetamide::US9789100, Example 5

SMILES: CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1

InChI Key: InChIKey=QHJCNRSZNUDPAO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 347317   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RET Kinase (aa 658-1114) (Homo sapiens (Human))	BDBM347317 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-10-19(14-32-25(23)36)16-5-6-17(22(28)9-16)11-24(35)33-20-8-7-18(13-26(2,3)15-34)21(12-20)27(29,30)31/h5-10,12,14,34H,4,11,13,15H2,1-3H3,(H,32,36)(H,33,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
RET Kinase (aa 658-1114) (Homo sapiens (Human))	BDBM347317 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-10-19(14-32-25(23)36)16-5-6-17(22(28)9-16)11-24(35)33-20-8-7-18(13-26(2,3)15-34)21(12-20)27(29,30)31/h5-10,12,14,34H,4,11,13,15H2,1-3H3,(H,32,36)(H,33,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
RET Kinase (aa 658-1114) (Homo sapiens (Human))	BDBM347317 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-10-19(14-32-25(23)36)16-5-6-17(22(28)9-16)11-24(35)33-20-8-7-18(13-26(2,3)15-34)21(12-20)27(29,30)31/h5-10,12,14,34H,4,11,13,15H2,1-3H3,(H,32,36)(H,33,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair