BDBM347581 2-(1-{[2-(Dimethylamino)pyridin-4-yl]carbonyl}piperidin-3-yl)benzonitrile::US9790201, 67

SMILES: CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1C#N

InChI Key: InChIKey=PUSLTXPCQICAAX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347581   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prokineticin receptor 1 (Homo sapiens (Human))	BDBM347581 (2-(1-{[2-(Dimethylamino)pyridin-4-yl]carbonyl}pipe...) Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1C#N Show InChI InChI=1S/C20H22N4O/c1-23(2)19-12-15(9-10-22-19)20(25)24-11-5-7-17(14-24)18-8-4-3-6-16(18)13-21/h3-4,6,8-10,12,17H,5,7,11,14H2,1-2H3	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...				US Patent US9790201 (2017) BindingDB Entry DOI: 10.7270/Q2377BVZ
					More data for this Ligand-Target Pair