BDBM34988 benzothienopyrimidinone deriv., 6e
SMILES: O[C@H]1CCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)C1
InChI Key: InChIKey=DSUSQUXNJRQJMI-VIFPVBQESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM34988 (benzothienopyrimidinone deriv., 6e) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 5 | -11.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ... | J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM34988 (benzothienopyrimidinone deriv., 6e) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 29 | -10.3 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Abbott Laboratories | Assay Description In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ... | J Med Chem 52: 6621-36 (2009) Article DOI: 10.1021/jm900943h BindingDB Entry DOI: 10.7270/Q27P8WQW | |||||||||||
More data for this Ligand-Target Pair |