null

SMILES: COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1

InChI Key: InChIKey=CYHGHBQCTXVJCN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350049   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM350049 (6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1 Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM350049 (6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1 Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 [397-806] (Homo sapiens (Human))	BDBM350049 (6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1 Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 [308-731] (Homo sapiens (Human))	BDBM350049 (6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1 Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...				US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 [403-822] (Homo sapiens (Human))	BDBM350049 (6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1 Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020) BindingDB Entry DOI: 10.7270/Q2BZ693Q
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM350049 (6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1 Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair