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BDBM350248 US10208056, Compound 75

SMILES: CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1C(F)(F)F

InChI Key:

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350248   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK8/Cyclin C


(Homo sapiens (Human))
BDBM350248
PNG
(US10208056, Compound 75)
Show SMILES CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1C(F)(F)F |(-2.34,4.02,;-.85,3.62,;-.45,2.13,;1.07,1.89,;2.16,2.98,;1.76,4.47,;3.64,2.58,;1.31,.37,;-.06,-.33,;-1.15,.76,;-2.64,.36,;-3.73,1.45,;-5.22,1.05,;-5.62,-.44,;-4.53,-1.53,;-3.04,-1.13,;-1.95,-2.22,;-.46,-1.82,;-.86,-3.31,;1.02,-1.42,;2.64,-.4,;3.73,.69,;5.22,.29,;5.62,-1.2,;4.53,-2.29,;3.04,-1.89,;1.95,-2.98,;2.35,-4.47,;.46,-2.58,;.86,-4.07,)|
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14.4n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent




US Patent US10208056 (2019)

More data for this
Ligand-Target Pair
CDK19/Cyclin C


(Homo sapiens (Human))
BDBM350248
PNG
(US10208056, Compound 75)
Show SMILES CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1C(F)(F)F |(-2.34,4.02,;-.85,3.62,;-.45,2.13,;1.07,1.89,;2.16,2.98,;1.76,4.47,;3.64,2.58,;1.31,.37,;-.06,-.33,;-1.15,.76,;-2.64,.36,;-3.73,1.45,;-5.22,1.05,;-5.62,-.44,;-4.53,-1.53,;-3.04,-1.13,;-1.95,-2.22,;-.46,-1.82,;-.86,-3.31,;1.02,-1.42,;2.64,-.4,;3.73,.69,;5.22,.29,;5.62,-1.2,;4.53,-2.29,;3.04,-1.89,;1.95,-2.98,;2.35,-4.47,;.46,-2.58,;.86,-4.07,)|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16.7n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent




US Patent US10208056 (2019)

More data for this
Ligand-Target Pair
haspin


(Homo sapiens (Human))
BDBM350248
PNG
(US10208056, Compound 75)
Show SMILES CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1C(F)(F)F |(-2.34,4.02,;-.85,3.62,;-.45,2.13,;1.07,1.89,;2.16,2.98,;1.76,4.47,;3.64,2.58,;1.31,.37,;-.06,-.33,;-1.15,.76,;-2.64,.36,;-3.73,1.45,;-5.22,1.05,;-5.62,-.44,;-4.53,-1.53,;-3.04,-1.13,;-1.95,-2.22,;-.46,-1.82,;-.86,-3.31,;1.02,-1.42,;2.64,-.4,;3.73,.69,;5.22,.29,;5.62,-1.2,;4.53,-2.29,;3.04,-1.89,;1.95,-2.98,;2.35,-4.47,;.46,-2.58,;.86,-4.07,)|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 233n/an/an/an/an/an/a



FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

US Patent




US Patent US10208056 (2019)

More data for this
Ligand-Target Pair