BDBM350554 1-[2-(3-aminopropyl)-3-(4- cyanophenyl)-1-oxo-1,2,3,4- tetrahydroisoquinolin-7-yl]-3- [4-(methylsulfanyl)phenyl]urea::US10208071, Compound 16::US10434112, Compound 36::US10799518, Compound 36

SMILES: CSc1ccc(NC(=O)Nc2ccc3CC(N(CCCN)C(=O)c3c2)c2ccc(cc2)C#N)cc1

InChI Key: InChIKey=NXVCYSRQNARCQL-UHFFFAOYSA-N

Data: 5 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 350554   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM350554 (1-[2-(3-aminopropyl)-3-(4- cyanophenyl)-1-oxo-1,2,...) Show SMILES CSc1ccc(NC(=O)Nc2ccc3CC(N(CCCN)C(=O)c3c2)c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C27H27N5O2S/c1-35-23-11-9-21(10-12-23)30-27(34)31-22-8-7-20-15-25(19-5-3-18(17-29)4-6-19)32(14-2-13-28)26(33)24(20)16-22/h3-12,16,25H,2,13-15,28H2,1H3,(H2,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...				US Patent US10208071 (2019) BindingDB Entry DOI: 10.7270/Q2TH8PT9
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM350554 (1-[2-(3-aminopropyl)-3-(4- cyanophenyl)-1-oxo-1,2,...) Show SMILES CSc1ccc(NC(=O)Nc2ccc3CC(N(CCCN)C(=O)c3c2)c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C27H27N5O2S/c1-35-23-11-9-21(10-12-23)30-27(34)31-22-8-7-20-15-25(19-5-3-18(17-29)4-6-19)32(14-2-13-28)26(33)24(20)16-22/h3-12,16,25H,2,13-15,28H2,1H3,(H2,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...				US Patent US10434112 (2019) BindingDB Entry DOI: 10.7270/Q2HX1G16
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM350554 (1-[2-(3-aminopropyl)-3-(4- cyanophenyl)-1-oxo-1,2,...) Show SMILES CSc1ccc(NC(=O)Nc2ccc3CC(N(CCCN)C(=O)c3c2)c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C27H27N5O2S/c1-35-23-11-9-21(10-12-23)30-27(34)31-22-8-7-20-15-25(19-5-3-18(17-29)4-6-19)32(14-2-13-28)26(33)24(20)16-22/h3-12,16,25H,2,13-15,28H2,1H3,(H2,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...				US Patent US10799518 (2020)
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM350554 (1-[2-(3-aminopropyl)-3-(4- cyanophenyl)-1-oxo-1,2,...) Show SMILES CSc1ccc(NC(=O)Nc2ccc3CC(N(CCCN)C(=O)c3c2)c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C27H27N5O2S/c1-35-23-11-9-21(10-12-23)30-27(34)31-22-8-7-20-15-25(19-5-3-18(17-29)4-6-19)32(14-2-13-28)26(33)24(20)16-22/h3-12,16,25H,2,13-15,28H2,1H3,(H2,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...				US Patent US10799518 (2020)
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM350554 (1-[2-(3-aminopropyl)-3-(4- cyanophenyl)-1-oxo-1,2,...) Show SMILES CSc1ccc(NC(=O)Nc2ccc3CC(N(CCCN)C(=O)c3c2)c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C27H27N5O2S/c1-35-23-11-9-21(10-12-23)30-27(34)31-22-8-7-20-15-25(19-5-3-18(17-29)4-6-19)32(14-2-13-28)26(33)24(20)16-22/h3-12,16,25H,2,13-15,28H2,1H3,(H2,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...				US Patent US10434112 (2019) BindingDB Entry DOI: 10.7270/Q2HX1G16
					More data for this Ligand-Target Pair