Found 2 hits for monomerid = 354669 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B2
(Homo sapiens (Human)) | BDBM354669
(US9809582, Example 12)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CCN2CCC(CC2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)cc1 |r,wU:10.22,wD:39.41,(-6.67,-9.24,;-5.33,-10.01,;-4,-9.24,;-2.67,-10.01,;-1.33,-9.24,;-1.33,-7.7,;-2.67,-6.93,;-4,-7.7,;-5.33,-6.93,;-6.67,-7.7,;,-6.93,;1.33,-7.7,;2.67,-6.93,;4,-7.7,;4,-9.24,;5.33,-6.93,;5.33,-5.39,;6.67,-4.62,;4,-4.62,;2.67,-5.39,;1.33,-4.62,;,-5.39,;-1.33,-4.62,;-2.67,-5.39,;-1.33,-3.08,;,-2.31,;,-.77,;-1.33,,;-1.33,1.54,;,2.31,;,3.85,;1.33,4.62,;1.33,6.16,;,6.93,;-1.33,6.16,;-1.33,4.62,;1.33,7.7,;1.33,9.24,;2.67,6.93,;4,7.7,;5.33,6.93,;6.67,7.7,;6.67,9.24,;5.33,10.01,;4,9.24,;5.54,9.24,;5.13,7.7,;-1.33,7.7,;-1.33,9.24,;-2.67,10.01,;-4,9.24,;-4,7.7,;-2.67,6.93,;-2.67,-.77,;-2.67,-2.31,)| Show InChI InChI=1S/C43H47Cl2N3O7/c1-52-37-13-12-32(24-39(37)53-2)38(25-34-35(44)26-48(51)27-36(34)45)54-41(49)31-10-8-29(9-11-31)14-19-46-22-17-43(18-23-46,33-6-4-3-5-7-33)42(50)55-40-28-47-20-15-30(40)16-21-47/h3-13,24,26-27,30,38,40H,14-23,25,28H2,1-2H3/t38-,40-/m0/s1 | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIESI FARMACEUTICI S.p.A.
US Patent
| Assay Description
PDE4B2 activity is detected using the LANCE Ultra cAMP homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay from Perkin E... |
US Patent US9809582 (2017)
BindingDB Entry DOI: 10.7270/Q2H1345N |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM354669
(US9809582, Example 12)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CCN2CCC(CC2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)cc1 |r,wU:10.22,wD:39.41,(-6.67,-9.24,;-5.33,-10.01,;-4,-9.24,;-2.67,-10.01,;-1.33,-9.24,;-1.33,-7.7,;-2.67,-6.93,;-4,-7.7,;-5.33,-6.93,;-6.67,-7.7,;,-6.93,;1.33,-7.7,;2.67,-6.93,;4,-7.7,;4,-9.24,;5.33,-6.93,;5.33,-5.39,;6.67,-4.62,;4,-4.62,;2.67,-5.39,;1.33,-4.62,;,-5.39,;-1.33,-4.62,;-2.67,-5.39,;-1.33,-3.08,;,-2.31,;,-.77,;-1.33,,;-1.33,1.54,;,2.31,;,3.85,;1.33,4.62,;1.33,6.16,;,6.93,;-1.33,6.16,;-1.33,4.62,;1.33,7.7,;1.33,9.24,;2.67,6.93,;4,7.7,;5.33,6.93,;6.67,7.7,;6.67,9.24,;5.33,10.01,;4,9.24,;5.54,9.24,;5.13,7.7,;-1.33,7.7,;-1.33,9.24,;-2.67,10.01,;-4,9.24,;-4,7.7,;-2.67,6.93,;-2.67,-.77,;-2.67,-2.31,)| Show InChI InChI=1S/C43H47Cl2N3O7/c1-52-37-13-12-32(24-39(37)53-2)38(25-34-35(44)26-48(51)27-36(34)45)54-41(49)31-10-8-29(9-11-31)14-19-46-22-17-43(18-23-46,33-6-4-3-5-7-33)42(50)55-40-28-47-20-15-30(40)16-21-47/h3-13,24,26-27,30,38,40H,14-23,25,28H2,1-2H3/t38-,40-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIESI FARMACEUTICI S.p.A.
US Patent
| Assay Description
Human M3 receptor membranes (15 μg/well) from Perkin Elmer are incubated with 0.52 nM Scopolamine Methyl Chloride, [N-methyl-3H] with or without... |
US Patent US9809582 (2017)
BindingDB Entry DOI: 10.7270/Q2H1345N |
More data for this
Ligand-Target Pair | |
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