Found 2 hits for monomerid = 354671 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B2
(Homo sapiens (Human)) | BDBM354671
(US9809582, Example 15)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CN2CC(C2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,wD:36.38,(-20.34,-18.96,;-19.01,-19.73,;-17.68,-18.96,;-16.34,-19.73,;-15.01,-18.96,;-15.01,-17.42,;-16.34,-16.65,;-17.68,-17.42,;-19.01,-16.65,;-20.34,-17.42,;-13.67,-16.65,;-12.34,-17.42,;-11.01,-16.65,;-11.01,-15.11,;-12.34,-14.34,;-9.67,-14.34,;-8.34,-15.11,;-7.01,-14.34,;-8.34,-16.65,;-9.67,-17.42,;-9.67,-18.96,;-13.67,-15.11,;-15.01,-14.34,;-16.34,-15.11,;-15.01,-12.8,;-16.25,-11.89,;-15.78,-10.43,;-14.24,-10.43,;-13.47,-9.09,;-14.24,-7.76,;-15.33,-6.67,;-14.24,-5.58,;-13.15,-6.67,;-12.9,-4.81,;-12.9,-3.27,;-11.57,-5.58,;-10.24,-4.81,;-8.9,-5.58,;-7.57,-4.81,;-7.57,-3.27,;-8.9,-2.5,;-10.24,-3.27,;-8.7,-3.27,;-9.47,-4.6,;-15.57,-4.81,;-16.91,-5.58,;-18.24,-4.81,;-18.24,-3.27,;-16.91,-2.5,;-15.57,-3.27,;-13.76,-11.89,)| Show InChI InChI=1S/C38H39Cl2N3O7S/c1-47-31-10-8-25(16-33(31)48-2)32(17-28-29(39)19-43(46)20-30(28)40)49-36(44)35-11-9-27(51-35)18-42-22-38(23-42,26-6-4-3-5-7-26)37(45)50-34-21-41-14-12-24(34)13-15-41/h3-11,16,19-20,24,32,34H,12-15,17-18,21-23H2,1-2H3/t32-,34-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIESI FARMACEUTICI S.p.A.
US Patent
| Assay Description PDE4B2 activity is detected using the LANCE Ultra cAMP homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay from Perkin E... |
US Patent US9809582 (2017)
BindingDB Entry DOI: 10.7270/Q2H1345N |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM354671
(US9809582, Example 15)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CN2CC(C2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,wD:36.38,(-20.34,-18.96,;-19.01,-19.73,;-17.68,-18.96,;-16.34,-19.73,;-15.01,-18.96,;-15.01,-17.42,;-16.34,-16.65,;-17.68,-17.42,;-19.01,-16.65,;-20.34,-17.42,;-13.67,-16.65,;-12.34,-17.42,;-11.01,-16.65,;-11.01,-15.11,;-12.34,-14.34,;-9.67,-14.34,;-8.34,-15.11,;-7.01,-14.34,;-8.34,-16.65,;-9.67,-17.42,;-9.67,-18.96,;-13.67,-15.11,;-15.01,-14.34,;-16.34,-15.11,;-15.01,-12.8,;-16.25,-11.89,;-15.78,-10.43,;-14.24,-10.43,;-13.47,-9.09,;-14.24,-7.76,;-15.33,-6.67,;-14.24,-5.58,;-13.15,-6.67,;-12.9,-4.81,;-12.9,-3.27,;-11.57,-5.58,;-10.24,-4.81,;-8.9,-5.58,;-7.57,-4.81,;-7.57,-3.27,;-8.9,-2.5,;-10.24,-3.27,;-8.7,-3.27,;-9.47,-4.6,;-15.57,-4.81,;-16.91,-5.58,;-18.24,-4.81,;-18.24,-3.27,;-16.91,-2.5,;-15.57,-3.27,;-13.76,-11.89,)| Show InChI InChI=1S/C38H39Cl2N3O7S/c1-47-31-10-8-25(16-33(31)48-2)32(17-28-29(39)19-43(46)20-30(28)40)49-36(44)35-11-9-27(51-35)18-42-22-38(23-42,26-6-4-3-5-7-26)37(45)50-34-21-41-14-12-24(34)13-15-41/h3-11,16,19-20,24,32,34H,12-15,17-18,21-23H2,1-2H3/t32-,34-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIESI FARMACEUTICI S.p.A.
US Patent
| Assay Description Human M3 receptor membranes (15 μg/well) from Perkin Elmer are incubated with 0.52 nM Scopolamine Methyl Chloride, [N-methyl-3H] with or without... |
US Patent US9809582 (2017)
BindingDB Entry DOI: 10.7270/Q2H1345N |
More data for this Ligand-Target Pair | |