BDBM354760 Preparation of 2-(3,4-dimethoxyphenyl)-7-(1H-indol-5-yl)-5H-pyrrolo[3,2-b]pyrazine ::US10485800, Example 37::US9814704, Example 37

SMILES: COc1ccc(cc1OC)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1

InChI Key: InChIKey=XPNPPOQHYUISHS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354760   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354760 (Preparation of 2-(3,4-dimethoxyphenyl)-7-(1H-indol...) Show SMILES COc1ccc(cc1OC)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1 Show InChI InChI=1S/C22H18N4O2/c1-27-19-6-4-14(10-20(19)28-2)18-12-25-22-21(26-18)16(11-24-22)13-3-5-17-15(9-13)7-8-23-17/h3-12,23H,1-2H3,(H,24,25)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354760 (Preparation of 2-(3,4-dimethoxyphenyl)-7-(1H-indol...) Show SMILES COc1ccc(cc1OC)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1 Show InChI InChI=1S/C22H18N4O2/c1-27-19-6-4-14(10-20(19)28-2)18-12-25-22-21(26-18)16(11-24-22)13-3-5-17-15(9-13)7-8-23-17/h3-12,23H,1-2H3,(H,24,25)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair