BDBM354799 1-cyclopentyl-6-(4- hydroxyphenyl)-1H- imidazo[4,5-b]pyrazin- 2(3H)-one::US10485800, Example 76::US9814704, Example 76

SMILES: Oc1ccc(cc1)-c1cnc2[nH]c(=O)n(C3CCCC3)c2n1

InChI Key: InChIKey=ICFDZIRYJSCARC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354799   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354799 (1-cyclopentyl-6-(4- hydroxyphenyl)-1H- imidazo[4,5...) Show SMILES Oc1ccc(cc1)-c1cnc2[nH]c(=O)n(C3CCCC3)c2n1 Show InChI InChI=1S/C16H16N4O2/c21-12-7-5-10(6-8-12)13-9-17-14-15(18-13)20(16(22)19-14)11-3-1-2-4-11/h5-9,11,21H,1-4H2,(H,17,19,22)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354799 (1-cyclopentyl-6-(4- hydroxyphenyl)-1H- imidazo[4,5...) Show SMILES Oc1ccc(cc1)-c1cnc2[nH]c(=O)n(C3CCCC3)c2n1 Show InChI InChI=1S/C16H16N4O2/c21-12-7-5-10(6-8-12)13-9-17-14-15(18-13)20(16(22)19-14)11-3-1-2-4-11/h5-9,11,21H,1-4H2,(H,17,19,22)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair