BDBM354819 1-(benzo[d]thiazol-5-yl)-6- (3,4,5-trimethoxyphenyl)- 1H-imidazo[4,5-b]pyrazin- 2(3H)-one::US10485800, Example 96::US9814704, Example 96

SMILES: COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(-c3ccc4scnc4c3)c2n1

InChI Key: InChIKey=USCMOXDGABWNQM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354819   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354819 (1-(benzo[d]thiazol-5-yl)-6- (3,4,5-trimethoxypheny...) Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(-c3ccc4scnc4c3)c2n1 Show InChI InChI=1S/C21H17N5O4S/c1-28-15-6-11(7-16(29-2)18(15)30-3)14-9-22-19-20(24-14)26(21(27)25-19)12-4-5-17-13(8-12)23-10-31-17/h4-10H,1-3H3,(H,22,25,27)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354819 (1-(benzo[d]thiazol-5-yl)-6- (3,4,5-trimethoxypheny...) Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2[nH]c(=O)n(-c3ccc4scnc4c3)c2n1 Show InChI InChI=1S/C21H17N5O4S/c1-28-15-6-11(7-16(29-2)18(15)30-3)14-9-22-19-20(24-14)26(21(27)25-19)12-4-5-17-13(8-12)23-10-31-17/h4-10H,1-3H3,(H,22,25,27)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair