BDBM356189 US9815846, Compound 189

SMILES: Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1ccc(nc1-c1ccccc1)C1CCC(=O)N1

InChI Key: InChIKey=IIUUPBNZQBOOIT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356189 (US9815846, Compound 189) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1ccc(nc1-c1ccccc1)C1CCC(=O)N1 Show InChI InChI=1S/C27H22F3N5O2/c1-35-14-13-20(34-35)18-15-17(7-8-19(18)27(28,29)30)26(37)33-23-10-9-22(21-11-12-24(36)31-21)32-25(23)16-5-3-2-4-6-16/h2-10,13-15,21H,11-12H2,1H3,(H,31,36)(H,33,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair