BDBM357752 KM-05-126/(I-12)::US10214530, Example 12
SMILES: Fc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1
InChI Key: InChIKey=HLFAVWDNJHBPGF-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human)) | BDBM357752 (KM-05-126/(I-12) | US10214530, Example 12) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent | Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in... | US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human)) | BDBM357752 (KM-05-126/(I-12) | US10214530, Example 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent | Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in... | US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK | |||||||||||
More data for this Ligand-Target Pair |