null
SMILES: Cn1c2nc(Sc3nc4cc(NC(=O)C[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human)) | BDBM357766![]() (KM477/(I-40) | US10214530, Example 46) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent | Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in... | US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human)) | BDBM357766![]() (KM477/(I-40) | US10214530, Example 46) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent | Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in... | US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK | |||||||||||
More data for this Ligand-Target Pair |