null
SMILES: Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(Cl)c(F)c1
InChI Key: InChIKey=JHDUWKAMESXEJC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuromedin-K receptor (Homo sapiens (Human)) | BDBM357793![]() ((4-chloro-3- fluorophenyl)(3-(3-methyl- 1,2,4-thia...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza | Assay Description NK-2/NK-3: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 recep... | J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2N58PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuromedin-K receptor (Homo sapiens (Human)) | BDBM357793![]() ((4-chloro-3- fluorophenyl)(3-(3-methyl- 1,2,4-thia...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
OGEDA SA US Patent | Assay Description The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra... | US Patent US10214533 (2019) BindingDB Entry DOI: 10.7270/Q21J9D35 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuromedin-K receptor (Homo sapiens (Human)) | BDBM357793![]() ((4-chloro-3- fluorophenyl)(3-(3-methyl- 1,2,4-thia...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza | Assay Description NK-2/NK-3: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 recep... | J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2N58PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-P receptor (Homo sapiens (Human)) | BDBM357793![]() ((4-chloro-3- fluorophenyl)(3-(3-methyl- 1,2,4-thia...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
OGEDA SA US Patent | Assay Description The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membra... | US Patent US10214533 (2019) BindingDB Entry DOI: 10.7270/Q21J9D35 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (Homo sapiens (Human)) | BDBM357793![]() ((4-chloro-3- fluorophenyl)(3-(3-methyl- 1,2,4-thia...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
OGEDA SA US Patent | Assay Description The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membra... | US Patent US10214533 (2019) BindingDB Entry DOI: 10.7270/Q21J9D35 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-P receptor (Homo sapiens (Human)) | BDBM357793![]() ((4-chloro-3- fluorophenyl)(3-(3-methyl- 1,2,4-thia...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza | Assay Description NK-1: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. ... | J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2N58PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (Homo sapiens (Human)) | BDBM357793![]() ((4-chloro-3- fluorophenyl)(3-(3-methyl- 1,2,4-thia...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza | Assay Description NK-2/NK-3: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 recep... | J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2N58PQZ | |||||||||||
More data for this Ligand-Target Pair |