BDBM35946 4-pyridinoxy-2-anilinopyridine-based compound, 10

SMILES: COc1ccccc1Nc1cc(Oc2cc(C)c(C)nc2-c2ccccn2)ccn1

InChI Key: InChIKey=TWHDGQOWPWNNCU-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 35946   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM35946 (4-pyridinoxy-2-anilinopyridine-based compound, 10) Show SMILES COc1ccccc1Nc1cc(Oc2cc(C)c(C)nc2-c2ccccn2)ccn1 Show InChI InChI=1S/C24H22N4O2/c1-16-14-22(24(27-17(16)2)20-9-6-7-12-25-20)30-18-11-13-26-23(15-18)28-19-8-4-5-10-21(19)29-3/h4-15H,1-3H3,(H,26,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	114	n/a	n/a	7.4	23
AstraZeneca					Assay Description A fluorescence polarization assay was used to assess the ALK5 binding capacity and biochemical activity of compounds. ALK5 protein was added to each ...				J Med Chem 52: 7901-5 (2009) Article DOI: 10.1021/jm900807w BindingDB Entry DOI: 10.7270/Q2KS6PXG
					More data for this Ligand-Target Pair