BDBM359497 US10221142, Example 2A

SMILES: OC(=O)c1cc(F)c(cc1O)-c1nn(C(=O)c2c(Cl)cccc2C2CC2)c2CCCCc12

InChI Key: InChIKey=FZTAEWRTJOUPAM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359497   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM359497 (US10221142, Example 2A) Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(C(=O)c2c(Cl)cccc2C2CC2)c2CCCCc12 Show InChI InChI=1S/C24H20ClFN2O4/c25-17-6-3-5-13(12-8-9-12)21(17)23(30)28-19-7-2-1-4-14(19)22(27-28)15-11-20(29)16(24(31)32)10-18(15)26/h3,5-6,10-12,29H,1-2,4,7-9H2,(H,31,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...				US Patent US10221142 (2019) BindingDB Entry DOI: 10.7270/Q2M90BZ0
					More data for this Ligand-Target Pair