BDBM360489 N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2-(3- (trifluoromethyl)phenyl)acetamide::US9828369, Example 48

SMILES: COc1cccc(c1)-c1ccc(CNC(=O)Cc2cccc(c2)C(F)(F)F)c2cnccc12

InChI Key: InChIKey=GRHRLHMSOBKXLE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360489   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM360489 (N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...) Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)Cc2cccc(c2)C(F)(F)F)c2cnccc12 Show InChI InChI=1S/C26H21F3N2O2/c1-33-21-7-3-5-18(14-21)22-9-8-19(24-16-30-11-10-23(22)24)15-31-25(32)13-17-4-2-6-20(12-17)26(27,28)29/h2-12,14,16H,13,15H2,1H3,(H,31,32)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	291	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharpe & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9828369 (2017) BindingDB Entry DOI: 10.7270/Q2DN47C7
					More data for this Ligand-Target Pair