BDBM360509 N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1,3-diphenyl-1H- pyrazole-4-carboxamide::US9828369, Example 66

SMILES: COc1cccc(c1)-c1ccc(CNC(=O)c2cn(nc2-c2ccccc2)-c2ccccc2)c2cnccc12

InChI Key: InChIKey=RYMMAKOWYGEHSG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360509   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM360509 (N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1...) Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cn(nc2-c2ccccc2)-c2ccccc2)c2cnccc12 Show InChI InChI=1S/C33H26N4O2/c1-39-27-14-8-11-24(19-27)28-16-15-25(30-21-34-18-17-29(28)30)20-35-33(38)31-22-37(26-12-6-3-7-13-26)36-32(31)23-9-4-2-5-10-23/h2-19,21-22H,20H2,1H3,(H,35,38)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	479	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharpe & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9828369 (2017) BindingDB Entry DOI: 10.7270/Q2DN47C7
					More data for this Ligand-Target Pair