BDBM3627 5-[(3-Bromophenyl)amino]-1-[2-(4-morpholino)ethyl]-pyrazolo[4,3-g]quinazoline::N-(3-bromophenyl)-1-[2-(morpholin-4-yl)ethyl]-1H-pyrazolo[4,3-g]quinazolin-5-amine::Pyrazoloquinazoline deriv. 2f

SMILES: Brc1cccc(Nc2ncnc3cc4n(CCN5CCOCC5)ncc4cc23)c1

InChI Key: InChIKey=ZNHHYTFVIUDETO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 3627   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3627 (5-[(3-Bromophenyl)amino]-1-[2-(4-morpholino)ethyl]...) Show SMILES Brc1cccc(Nc2ncnc3cc4n(CCN5CCOCC5)ncc4cc23)c1 Show InChI InChI=1S/C21H21BrN6O/c22-16-2-1-3-17(11-16)26-21-18-10-15-13-25-28(5-4-27-6-8-29-9-7-27)20(15)12-19(18)23-14-24-21/h1-3,10-14H,4-9H2,(H,23,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	191	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA				Eur J Med Chem 43: 781-91 (2008) Article DOI: 10.1016/j.ejmech.2007.06.006 BindingDB Entry DOI: 10.7270/Q2DJ5GXN
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3627 (5-[(3-Bromophenyl)amino]-1-[2-(4-morpholino)ethyl]...) Show SMILES Brc1cccc(Nc2ncnc3cc4n(CCN5CCOCC5)ncc4cc23)c1 Show InChI InChI=1S/C21H21BrN6O/c22-16-2-1-3-17(11-16)26-21-18-10-15-13-25-28(5-4-27-6-8-29-9-7-27)20(15)12-19(18)23-14-24-21/h1-3,10-14H,4-9H2,(H,23,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	7.4	25
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1519-29 (1997) Article DOI: 10.1021/jm960789h BindingDB Entry DOI: 10.7270/Q2SJ1HRQ
					More data for this Ligand-Target Pair