BDBM365216 1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxaborolan-2-yl)pyridin-3- yl]-1-benzothien-5-yl}-3-[4- chloro-3- (trifluoromethyl)phenyl]ure::US10633373, Example 25::US10669265, Example 25::US9868726, Example 25

SMILES: CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1

InChI Key: InChIKey=JSYLKKLOSDAHJF-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 365216   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM365216 (1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...) Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2DB8465
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM365216 (1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...) Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2DB8465
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM365216 (1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...) Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...				US Patent US10669265 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM365216 (1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...) Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Allergan, Inc. US Patent					Assay Description PDGFRβ: Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu...				US Patent US10633373 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM365216 (1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...) Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				US Patent US10669265 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM365216 (1-{2-[2-amino-5-(4,4,5,5- tetramethyl-1,3,2- dioxa...) Show SMILES CC1(C)OB(OC1(C)C)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C27H25BClF3N4O3S/c1-25(2)26(3,4)39-28(38-25)15-11-18(23(33)34-13-15)22-10-14-9-16(6-8-21(14)40-22)35-24(37)36-17-5-7-20(29)19(12-17)27(30,31)32/h5-13H,1-4H3,(H2,33,34)(H2,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Allergan, Inc. US Patent					Assay Description VEGFR2: Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:...				US Patent US10633373 (2020)
					More data for this Ligand-Target Pair