BDBM365280 1-Methyl-5-[2-((R)-2- methyl-pyrrolidin-1-yl)- 6-(4-trifluoromethyl- pyridin-2-ylamino)- pyrimidin-4-yl]-1H-pyridin- 2-one::US9868720, No. 331

SMILES: C[C@@H]1CCCN1c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)-c1ccc(=O)n(C)c1

InChI Key: InChIKey=VKMPQWHCBTZILM-CYBMUJFWSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365280   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365280 (1-Methyl-5-[2-((R)-2- methyl-pyrrolidin-1-yl)- 6-(...) Show SMILES C[C@@H]1CCCN1c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)-c1ccc(=O)n(C)c1 |r| Show InChI InChI=1S/C21H21F3N6O/c1-13-4-3-9-30(13)20-26-16(14-5-6-19(31)29(2)12-14)11-18(28-20)27-17-10-15(7-8-25-17)21(22,23)24/h5-8,10-13H,3-4,9H2,1-2H3,(H,25,26,27,28)/t13-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	18.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair