BDBM365304 (2-Methoxy-4-methyl- phenyl)-{3-[6-(4-methyl- pyridin-2-ylamino)-2-(2- methyl-pyrrolidin-1-yl)- pyrimidin-4-yl]-piperidin- 1-yl}-methanone::US9868720, No. 425

SMILES: COc1cc(C)ccc1C(=O)N1CCCC(C1)c1cc(Nc2cc(C)ccn2)nc(n1)N1CCCC1C

InChI Key: InChIKey=DBMHHJQHVRPUPO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365304   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365304 ((2-Methoxy-4-methyl- phenyl)-{3-[6-(4-methyl- pyri...) Show SMILES COc1cc(C)ccc1C(=O)N1CCCC(C1)c1cc(Nc2cc(C)ccn2)nc(n1)N1CCCC1C Show InChI InChI=1S/C29H36N6O2/c1-19-9-10-23(25(15-19)37-4)28(36)34-13-6-8-22(18-34)24-17-27(32-26-16-20(2)11-12-30-26)33-29(31-24)35-14-5-7-21(35)3/h9-12,15-17,21-22H,5-8,13-14,18H2,1-4H3,(H,30,31,32,33)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair