null

SMILES: COc1ccnc(NCCC#CCNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)n1

InChI Key: InChIKey=MUPKDDDPMOIBME-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366186   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366186 (US9873693, Compound 109 | US9873693, Compound 264) Show SMILES COc1ccnc(NCCC#CCNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)n1 Show InChI InChI=1S/C23H21F2N5O3/c1-33-20-9-12-28-23(29-20)27-11-4-2-3-10-26-21(31)17-6-5-13-30(22(17)32)15-16-7-8-18(24)19(25)14-16/h5-9,12-14H,4,10-11,15H2,1H3,(H,26,31)(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366186 (US9873693, Compound 109 | US9873693, Compound 264) Show SMILES COc1ccnc(NCCC#CCNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)n1 Show InChI InChI=1S/C23H21F2N5O3/c1-33-20-9-12-28-23(29-20)27-11-4-2-3-10-26-21(31)17-6-5-13-30(22(17)32)15-16-7-8-18(24)19(25)14-16/h5-9,12-14H,4,10-11,15H2,1H3,(H,26,31)(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair