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SMILES: Fc1cc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)C3CC3)c2=O)cc(F)c1F

InChI Key: InChIKey=BCVSIKDUEUUXOA-NRFANRHFSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 366245   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 [51-360]


(Homo sapiens (Human))		BDBM366245
PNG
(US9873693, Compound 168)
Show SMILES Fc1cc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)C3CC3)c2=O)cc(F)c1F |r|
Show InChI InChI=1S/C25H19F3N4O4/c26-17-8-13(9-18(27)22(17)28)11-32-7-1-2-16(24(32)34)23(33)29-21(14-3-4-14)12-36-15-5-6-19-20(10-15)31-25(35)30-19/h1-2,5-10,14,21H,3-4,11-12H2,(H,29,33)/t21-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Duquesne University



Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair