null

SMILES: CN(Cc1ccncc1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1

InChI Key: InChIKey=AOLYVYZAJDHUGC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367108   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM367108 (N-methyl-N-(4- pyridylmethyl)-4-[[8- [1-(4,4,4- tr...) Show SMILES CN(Cc1ccncc1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1 |t:28| Show InChI InChI=1S/C29H28F3N7O2/c1-37(19-20-9-14-33-15-10-20)27(41)22-4-6-23(7-5-22)34-28-35-26-24(3-2-16-39(26)36-28)21-11-17-38(18-12-21)25(40)8-13-29(30,31)32/h2-7,9-11,14-16H,8,12-13,17-19H2,1H3,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM367108 (N-methyl-N-(4- pyridylmethyl)-4-[[8- [1-(4,4,4- tr...) Show SMILES CN(Cc1ccncc1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1 |t:28| Show InChI InChI=1S/C29H28F3N7O2/c1-37(19-20-9-14-33-15-10-20)27(41)22-4-6-23(7-5-22)34-28-35-26-24(3-2-16-39(26)36-28)21-11-17-38(18-12-21)25(40)8-13-29(30,31)32/h2-7,9-11,14-16H,8,12-13,17-19H2,1H3,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair