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SMILES: CC(=O)Nc1cc(ccn1)-c1[nH]c2CC(C)(CC(=O)c2c1Nc1ccccc1)C(=O)N1CC2(COC2)C1

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 367491   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitotic checkpoint serine/threonine-protein kinase BUB1


(Homo sapiens (Human))		BDBM367491
PNG
(N-4-[(6RS)-6-Methyl-6-(2-oxa-6-azaspiro[3.3]hept-6...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1[nH]c2CC(C)(CC(=O)c2c1Nc1ccccc1)C(=O)N1CC2(COC2)C1 |w:14.31,14.15|
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US Patent
n/an/a 932n/an/an/an/an/an/a



Pfizer



Assay Description
Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...

J Med Chem 51: 1377-84 (2008)


BindingDB Entry DOI: 10.7270/Q2QN6931
More data for this
Ligand-Target Pair