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SMILES: CNC1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F

InChI Key: InChIKey=PWAQXCIQEQGNNA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 368239   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM368239
PNG
(US10227338, Example 20)
Show SMILES CNC1CCN(C1)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1S/C21H20ClF4N5O2S2/c1-27-13-4-5-31(9-13)18-6-12(21(24,25)26)2-3-16(18)29-17-8-15(23)19(7-14(17)22)35(32,33)30-20-10-34-11-28-20/h2-3,6-8,10-11,13,27,29-30H,4-5,9H2,1H3
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KEGG

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PC cid
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US Patent
n/an/a 21n/an/an/an/an/an/a



AstraZeneca



Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...

J Med Chem 51: 1755-1763 (2008)


BindingDB Entry DOI: 10.7270/Q2F47RFM
More data for this
Ligand-Target Pair