BDBM368316 US10227338, Example 103

SMILES: CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1ccc(F)cn1)C(=O)OC(C)(C)C

InChI Key: InChIKey=OJYDAFAJPRTDCF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368316   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM368316 (US10227338, Example 103) Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1ccc(F)cn1)C(=O)OC(C)(C)C Show InChI InChI=1S/C31H37ClF3N5O6S/c1-30(2,3)45-28(41)39(8)14-13-38(7)25-15-19(33)9-11-23(25)37-24-17-22(35)26(16-21(24)32)47(43,44)40(29(42)46-31(4,5)6)27-12-10-20(34)18-36-27/h9-12,15-18,37H,13-14H2,1-8H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...				J Med Chem 51: 1755-1763 (2008) BindingDB Entry DOI: 10.7270/Q2F47RFM
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM368316 (US10227338, Example 103) Show SMILES CN(CCN(C)c1cc(F)ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)N(C(=O)OC(C)(C)C)c1ccc(F)cn1)C(=O)OC(C)(C)C Show InChI InChI=1S/C31H37ClF3N5O6S/c1-30(2,3)45-28(41)39(8)14-13-38(7)25-15-19(33)9-11-23(25)37-24-17-22(35)26(16-21(24)32)47(43,44)40(29(42)46-31(4,5)6)27-12-10-20(34)18-36-27/h9-12,15-18,37H,13-14H2,1-8H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...				J Med Chem 51: 1755-1763 (2008) BindingDB Entry DOI: 10.7270/Q2F47RFM
					More data for this Ligand-Target Pair