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SMILES: Cn1nc(cc1-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C(F)(F)F

InChI Key: InChIKey=LEKGTHUFCFCMSD-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368511   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM368511
PNG
(1-(1-methyl-3- (trifluoromethyl)-1H- pyrazol-5-yl)...)
Show SMILES Cn1nc(cc1-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C(F)(F)F
Show InChI InChI=1S/C20H14F3N7/c1-30-15(10-16(29-30)20(21,22)23)17-13-5-4-12(9-11(13)6-8-25-17)26-19-18-14(27-28-19)3-2-7-24-18/h2-10H,1H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/an/an/a 132n/an/an/an/a


TBA

Assay Description
Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM

Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM368511
PNG
(1-(1-methyl-3- (trifluoromethyl)-1H- pyrazol-5-yl)...)
Show SMILES Cn1nc(cc1-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C(F)(F)F
Show InChI InChI=1S/C20H14F3N7/c1-30-15(10-16(29-30)20(21,22)23)17-13-5-4-12(9-11(13)6-8-25-17)26-19-18-14(27-28-19)3-2-7-24-18/h2-10H,1H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 132n/an/an/an/a



Universita di Napoli



Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

J Med Chem 51: 1764-70 (2008)


BindingDB Entry DOI: 10.7270/Q2X63Q8G
More data for this
Ligand-Target Pair