BDBM368520 N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluoromethyl) isoquinolin-6-amine::US10227343, Example 52

SMILES: FC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key: InChIKey=IMDIQNUECOXRNB-UHFFFAOYSA-N

Data: 1 EC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368520   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368520 (N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...) Show SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H10F3N5/c17-16(18,19)14-11-4-3-10(8-9(11)5-7-21-14)22-15-13-12(23-24-15)2-1-6-20-13/h1-8H,(H2,22,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2X63Q8G
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM368520 (N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...) Show SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H10F3N5/c17-16(18,19)14-11-4-3-10(8-9(11)5-7-21-14)22-15-13-12(23-24-15)2-1-6-20-13/h1-8H,(H2,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM				Citation and Details
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368520 (N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...) Show SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H10F3N5/c17-16(18,19)14-11-4-3-10(8-9(11)5-7-21-14)22-15-13-12(23-24-15)2-1-6-20-13/h1-8H,(H2,22,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl				Citation and Details
					More data for this Ligand-Target Pair