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SMILES: N(c1n[nH]c2cccnc12)c1ccc2cnccc2c1

InChI Key: InChIKey=OEWKDSKMXGOOPC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 368552   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368552 (N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...) Show SMILES N(c1n[nH]c2cccnc12)c1ccc2cnccc2c1 Show InChI InChI=1S/C15H11N5/c1-2-13-14(17-6-1)15(20-19-13)18-12-4-3-11-9-16-7-5-10(11)8-12/h1-9H,(H2,18,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2X63Q8G
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368552 (N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...) Show SMILES N(c1n[nH]c2cccnc12)c1ccc2cnccc2c1 Show InChI InChI=1S/C15H11N5/c1-2-13-14(17-6-1)15(20-19-13)18-12-4-3-11-9-16-7-5-10(11)8-12/h1-9H,(H2,18,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	76	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl				Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM368552 (N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...) Show SMILES N(c1n[nH]c2cccnc12)c1ccc2cnccc2c1 Show InChI InChI=1S/C15H11N5/c1-2-13-14(17-6-1)15(20-19-13)18-12-4-3-11-9-16-7-5-10(11)8-12/h1-9H,(H2,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM				Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM368552 (N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...) Show SMILES N(c1n[nH]c2cccnc12)c1ccc2cnccc2c1 Show InChI InChI=1S/C15H11N5/c1-2-13-14(17-6-1)15(20-19-13)18-12-4-3-11-9-16-7-5-10(11)8-12/h1-9H,(H2,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM				Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM368552 (N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...) Show SMILES N(c1n[nH]c2cccnc12)c1ccc2cnccc2c1 Show InChI InChI=1S/C15H11N5/c1-2-13-14(17-6-1)15(20-19-13)18-12-4-3-11-9-16-7-5-10(11)8-12/h1-9H,(H2,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl				Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM368552 (N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...) Show SMILES N(c1n[nH]c2cccnc12)c1ccc2cnccc2c1 Show InChI InChI=1S/C15H11N5/c1-2-13-14(17-6-1)15(20-19-13)18-12-4-3-11-9-16-7-5-10(11)8-12/h1-9H,(H2,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM				Citation and Details
					More data for this Ligand-Target Pair