BindingDB PrimarySearch

BDBM369944 (R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-cyclopentyl-2-oxoethyl)-2-fluoro-5-(trifluoromethyl)benzamide::US10233182, Example 57

SMILES: CN1C(=O)N(c2ccc3[nH]ncc3c2)C2(CCN(CC2)C(=O)[C@H](NC(=O)c2cc(ccc2F)C(F)(F)F)C2CCCC2)C1=O

InChI Key:

Data: 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369944
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM369944 ((R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
X-Chem, Inc. Curated by ChEMBL					Assay Description Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...				J Med Chem 63: 7840-7856 (2020)
X-Chem, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM369944 ((R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Merck Serono					Assay Description The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...				J Med Chem 51: 2227-2243 (2008) BindingDB Entry DOI: 10.7270/Q2QF8W5N
Merck Serono					More data for this Ligand-Target Pair