null

SMILES: Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(C)c2=O)S(=O)(=O)NC2(C)CC2)s1

InChI Key: InChIKey=NMGNSNUSOVFCDS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 371026   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM371026 (US10239843, Example 133) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(C)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H22N4O4S2/c1-11-16(28-12(2)20-11)10-23-15-6-5-13(29(26,27)21-19(3)7-8-19)9-14(15)17(24)22(4)18(23)25/h5-6,9,21H,7-8,10H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM371026 (US10239843, Example 133) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(C)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H22N4O4S2/c1-11-16(28-12(2)20-11)10-23-15-6-5-13(29(26,27)21-19(3)7-8-19)9-14(15)17(24)22(4)18(23)25/h5-6,9,21H,7-8,10H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
The University of Manchester Curated by ChEMBL					Assay Description Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assay				J Med Chem 61: 10767-10792 (2018) Article DOI: 10.1021/acs.jmedchem.8b01407 BindingDB Entry DOI: 10.7270/Q2TM7DTN
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM371026 (US10239843, Example 133) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(C)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H22N4O4S2/c1-11-16(28-12(2)20-11)10-23-15-6-5-13(29(26,27)21-19(3)7-8-19)9-14(15)17(24)22(4)18(23)25/h5-6,9,21H,7-8,10H2,1-4H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371026 (US10239843, Example 133) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(C)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H22N4O4S2/c1-11-16(28-12(2)20-11)10-23-15-6-5-13(29(26,27)21-19(3)7-8-19)9-14(15)17(24)22(4)18(23)25/h5-6,9,21H,7-8,10H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair