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SMILES: FC(F)(F)c1ccc([C@H]2CCOc3cc(ccc23)S(=O)(=O)Nc2ncccn2)c(c1)-c1nccs1

InChI Key: InChIKey=REOYNCMKRPSHKZ-QGZVFWFLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371667   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM371667
PNG
(N-(pyrimidin-2-yl)-4-(2-(thiazol-2-yl)-4-(trifluor...)
Show SMILES FC(F)(F)c1ccc([C@H]2CCOc3cc(ccc23)S(=O)(=O)Nc2ncccn2)c(c1)-c1nccs1 |r|
Show InChI InChI=1S/C23H17F3N4O3S2/c24-23(25,26)14-2-4-16(19(12-14)21-27-9-11-34-21)17-6-10-33-20-13-15(3-5-18(17)20)35(31,32)30-22-28-7-1-8-29-22/h1-5,7-9,11-13,17H,6,10H2,(H,28,29,30)/t17-/m1/s1
PDB

KEGG

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PC cid
PC sid
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US Patent
n/an/a 4n/an/an/an/an/an/a



University of California at San Francisco



Assay Description
HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...

J Med Chem 51: 545-52 (2008)


BindingDB Entry DOI: 10.7270/Q2NG4SZX
More data for this
Ligand-Target Pair