BDBM373110 1-[3-(1-methyl-1H- imidazol-2- yl)phenyl]-3-(2- phenylimidazo[1,2- a]pyridin-3-yl)urea::US9896447, Compound 27

SMILES: Cn1ccnc1-c1cccc(NC(=O)Nc2c(nc3ccccn23)-c2ccccc2)c1

InChI Key: InChIKey=SZNHNIQVPBEZEE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373110   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM373110 (1-[3-(1-methyl-1H- imidazol-2- yl)phenyl]-3-(2- ph...) Show SMILES Cn1ccnc1-c1cccc(NC(=O)Nc2c(nc3ccccn23)-c2ccccc2)c1 Show InChI InChI=1S/C24H20N6O/c1-29-15-13-25-22(29)18-10-7-11-19(16-18)26-24(31)28-23-21(17-8-3-2-4-9-17)27-20-12-5-6-14-30(20)23/h2-16H,1H3,(H2,26,28,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
IRBM-MRL					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...				J Med Chem 51: 861-74 (2008) BindingDB Entry DOI: 10.7270/Q26975VH
					More data for this Ligand-Target Pair