BDBM373630 US10604535, Example 114A::US9896458, No. 114A

SMILES: CN1c2cnn(C)c2CC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O

InChI Key: InChIKey=NKIKYIKDZGIZOR-HNNXBMFYSA-N

Data: 2 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373630   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM373630 (US10604535, Example 114A | US9896458, No. 114A) Show SMILES CN1c2cnn(C)c2CC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O |r| Show InChI InChI=1S/C20H21FN6O2/c1-25-17-10-22-26(2)16(17)9-8-15(20(25)29)23-19(28)18-14(21)12-27(24-18)11-13-6-4-3-5-7-13/h3-7,10,12,15H,8-9,11H2,1-2H3,(H,23,28)/t15-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapeutics Inc. US Patent					Assay Description Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...				US Patent US10604535 (2020)
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM373630 (US10604535, Example 114A | US9896458, No. 114A) Show SMILES CN1c2cnn(C)c2CC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O |r| Show InChI InChI=1S/C20H21FN6O2/c1-25-17-10-22-26(2)16(17)9-8-15(20(25)29)23-19(28)18-14(21)12-27(24-18)11-13-6-4-3-5-7-13/h3-7,10,12,15H,8-9,11H2,1-2H3,(H,23,28)/t15-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2XW4N44
					More data for this Ligand-Target Pair